A basic review on estrogen receptor signaling pathways in breast cancer
L Clusan, F Ferrière, G Flouriot, F Pakdel - International journal of …, 2023 - mdpi.com
Breast cancer is the most common cancer and the deadliest among women worldwide.
Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen …
Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen …
Decoding endoplasmic reticulum stress signals in cancer cells and antitumor immunity
C Salvagno, JK Mandula, PC Rodriguez… - Trends in cancer, 2022 - cell.com
The tumor microenvironment (TME) provokes endoplasmic reticulum (ER) stress in
malignant cells and infiltrating immune populations. Sensing and responding to ER stress is …
malignant cells and infiltrating immune populations. Sensing and responding to ER stress is …
Transcription factors interact with RNA to regulate genes
O Oksuz, JE Henninger, R Warneford-Thomson… - Molecular cell, 2023 - cell.com
Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
[HTML][HTML] Gene regulation by gonadal hormone receptors underlies brain sex differences
Oestradiol establishes neural sex differences in many vertebrates 1, 2, 3 and modulates
mood, behaviour and energy balance in adulthood 4, 5, 6, 7, 8. In the canonical pathway …
mood, behaviour and energy balance in adulthood 4, 5, 6, 7, 8. In the canonical pathway …
CPSF6-mediated XBP1 3'UTR shortening attenuates cisplatin-induced ER stress and elevates chemo-resistance in lung adenocarcinoma
C Zhu, Y Xie, Q Li, Z Zhang, J Chen, K Zhang… - Drug Resistance …, 2023 - Elsevier
Alternative polyadenylation (APA) is a widespread mechanism generating RNA molecules
with alternative 3'ends. Herein, we discovered that TargetScan includes a novel XBP1 …
with alternative 3'ends. Herein, we discovered that TargetScan includes a novel XBP1 …
RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis
H Zhu, K Chen, Y Chen, J Liu, X Zhang… - Signal transduction and …, 2022 - nature.com
RNA-binding proteins (RBPs) play important roles in cancer development and treatment.
However, the tumor-promoting RBPs and their partners, which may potentially serve as the …
However, the tumor-promoting RBPs and their partners, which may potentially serve as the …
Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
Y Cen, L Chen, Z Liu, Q Lin, X Fang, H Yao… - Cell death …, 2023 - nature.com
Therapy resistance remains a huge challenge for current breast cancer treatments.
Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for …
Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for …
Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics
Q Peng, Y Zhou, L Oyang, N Wu, Y Tang, M Su, X Luo… - Molecular Therapy, 2022 - cell.com
Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …
Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …