T cells exercise a multitude of functions such as cytotoxicity, secretion of immunomodulating
cytokines or regulation of tolerance, collectively resulting in an effective control of immune …

Most lymphocytes express cell surface Ag receptor chains from single alleles of distinct Ig or
TCR loci. Since the identification of Ag receptor allelic exclusion, the importance of this …

Lung complications are a major cause of rheumatoid arthritis-related mortality. Involvement
of gut microbiota in lung diseases by the gut-lung axis has been widely observed, but the …

The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains,
called α and β, to recognize pathogens. Using results of high throughput sequencing and …

Allelic exclusion, one lymphocyte expresses one antigen receptor, is a fundamental
mechanism of immunological self-tolerance and highly specific immune responses to …

Dual TCR T cells are a common and natural product of TCR gene rearrangement and
thymocyte development. As much as one third of the T cell population may have the …

Gene regulation relies on dynamic changes in three-dimensional chromatin conformation,
which are shaped by composite regulatory and architectural elements. However …

The monoallelic expression of antigen receptor (AgR) genes, called allelic exclusion, is
fundamental for highly specific immune responses to pathogens. This cardinal feature of …

Current tumor immunotherapy approaches include the genetic modification of peripheral T
cells to express tumor antigen-specific T-cell receptors (TCRs). The approach, tested in …

The HuR RNA-binding protein posttranscriptionally controls expression of genes involved in
cellular survival, proliferation, and differentiation. To determine roles of HuR in B cell …