Simple Summary One hundred years ago, it was discovered that some cancer cells have a
different metabolism from normal cells. This alternative metabolism is called the Warburg …

Metabolic alterations are established as a hallmark of cancer. Such hallmark changes in
cancer metabolism are characterized by reprogramming of energy-producing pathways and …

Oligodendrogliomas are primary human brain tumors with a characteristic 1p/19q co-
deletion of important prognostic relevance, but little is known about the pathology of this …

Objective Cancer metabolic reprogramming promotes resistance to therapies. In this study,
we addressed the role of the Warburg effect in the resistance to photodynamic therapy (PDT) …

Wilson disease (WD), a genetic disorder affecting copper transport, is characterized by
hepatic and neurological manifestations with variable and often unpredictable presentation …

When tissues are under physiological stresses, such as vigorous exercise and cold
exposure, skeletal muscle cells secrete succinate into the extracellular space for adaptation …

Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has
been found to have anti-cancer effects in a variety of malignancies including high grade …

Obesity is a significant risk factor for ovarian cancer (OC) and associated with worse
outcomes for this disease. We assessed the anti-tumorigenic effects of metformin in human …

Abnormalities in tricarboxylic acid (TCA) cycle function were related to a variety of
pathological processes. Fumarate hydratase (FH) is a required enzyme in the TCA cycle. To …

Abstract Development of phosphohistidine (pHis) antibodies has significantly advanced our
understanding of pHis contributions to tumor biology, including a tumor suppressive role for …