The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

Advanced glycation end products (AGEs) are a heterogeneous group of molecules
produced, non‐enzymatically, from the interaction between reducing sugars and the free …

Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid
adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is …

Methylglyoxal (MG) is a potent protein glycating agent. Glycation is directed to guanidino
groups of arginine residues forming mainly hydroimidazolone N δ-(5-hydro-5-methyl-4 …

The glyoxalase system is a ubiquitous enzymatic network which plays important roles in
biological life. It consists of glyoxalase 1 (GLO1), glyoxalase 2 (GLO2), and reduced …

This protocol describes a method for the detection and quantification of methylglyoxal (MG),
the major physiological substrate of the cytosolic glyoxalase system. Accumulation of MG …

Chronic complications of diabetes are due to myriad disorders of numerous metabolic
pathways that are responsible for most of the morbidity and mortality associated with the …