Function of alternative splicing
O Kelemen, P Convertini, Z Zhang, Y Wen, M Shen… - Gene, 2013 - Elsevier
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …
the functions of alternative splicing events that have been experimentally determined. The …
Insects as innovative models for functional studies of DNA methylation
F Lyko, R Maleszka - Trends in genetics, 2011 - cell.com
The emerging field of epigenomics has the potential to bridge the gap between static
genomic sequences and complex phenotypes that arise from multigenic, nonlinear and …
genomic sequences and complex phenotypes that arise from multigenic, nonlinear and …
Chromatin and epigenetic regulation of pre-mRNA processing
New data are revealing a complex landscape of gene regulation shaped by chromatin states
that extend into the bodies of transcribed genes and associate with distinct RNA elements …
that extend into the bodies of transcribed genes and associate with distinct RNA elements …
Deciphering the plant splicing code: experimental and computational approaches for predicting alternative splicing and splicing regulatory elements
Extensive alternative splicing (AS) of precursor mRNAs (pre-mRNAs) in multicellular
eukaryotes increases the protein-coding capacity of a genome and allows novel ways to …
eukaryotes increases the protein-coding capacity of a genome and allows novel ways to …
Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins
Alternative pre-mRNA splicing provides a source of vast protein diversity by removing non-
coding sequences (introns) and accurately linking different exonic regions in the correct …
coding sequences (introns) and accurately linking different exonic regions in the correct …
Sudemycin E influences alternative splicing and changes chromatin modifications
P Convertini, M Shen, PM Potter… - Nucleic acids …, 2014 - academic.oup.com
Sudemycin E is an analog of the pre-messenger RNA splicing modulator FR901464 and its
derivative spliceostatin A. Sudemycin E causes the death of cancer cells through an …
derivative spliceostatin A. Sudemycin E causes the death of cancer cells through an …
Evidence for the role of transcription factors in the co-transcriptional regulation of intron retention
Background Alternative splicing is a widespread regulatory phenomenon that enables a
single gene to produce multiple transcripts. Among the different types of alternative splicing …
single gene to produce multiple transcripts. Among the different types of alternative splicing …
Perturbation of chromatin structure globally affects localization and recruitment of splicing factors
Chromatin structure is an important factor in the functional coupling between transcription
and mRNA processing, not only by regulating alternative splicing events, but also by …
and mRNA processing, not only by regulating alternative splicing events, but also by …
The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit
CB Zraly, AK Dingwall - Nucleic acids research, 2012 - academic.oup.com
Nucleosome remodeling catalyzed by the ATP-dependent SWI/SNF complex is essential for
regulated gene expression. Transcriptome profiling studies in flies and mammals identified …
regulated gene expression. Transcriptome profiling studies in flies and mammals identified …
Chromatin and alternative splicing
Alternative splicing affects more than 90% of human genes. Coupling between transcription
and splicing has become crucial in the complex network underlying alternative splicing …
and splicing has become crucial in the complex network underlying alternative splicing …