Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases

I Grosjean, B Roméo, MA Domdom, A Belaid… - Autophagy, 2022 - Taylor & Francis
At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria

I Abdelli, F Hassani, S Bekkel Brikci… - Journal of Biomolecular …, 2021 - Taylor & Francis
The objective of this present study is to focus on the in silico study to screen for an
alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as …

New techniques and strategies in drug discovery

J Du, J Guo, D Kang, Z Li, G Wang, J Wu, Z Zhang… - Chinese Chemical …, 2020 - Elsevier
Great success has been witnessed in last decades, some new techniques and strategies
have been widely used in drug discovery. In this roadmap, several representative …

In Silico Prediction of a Multitope Vaccine against Moraxella catarrhalis: Reverse Vaccinology and Immunoinformatics

MA Soltan, N Elbassiouny, H Gamal, EB Elkaeed… - Vaccines, 2021 - mdpi.com
Moraxella catarrhalis (M. catarrhalis) is a Gram-negative bacterium that can cause serious
respiratory tract infections and middle ear infections in children and adults. M. catarrhalis …

Immunoinformatics-guided designing and in silico analysis of epitope-based polyvalent vaccines against multiple strains of human coronavirus (HCoV)

B Sarkar, MA Ullah, Y Araf, NN Islam… - Expert review of …, 2022 - Taylor & Francis
Objectives The group of human coronaviruses (HCoVs) consists of some highly pathogenic
viruses that have caused several outbreaks in the past. The newly emerged strain of HCoV …

Exploiting the reverse vaccinology approach to design novel subunit vaccines against Ebola virus

MA Ullah, B Sarkar, SS Islam - Immunobiology, 2020 - Elsevier
Ebola virus is a highly pathogenic RNA virus that causes the Ebola haemorrhagic fever in
human. This virus is considered as one of the dangerous viruses in the world with very high …

Reverse vaccinology approach to design a novel multi-epitope subunit vaccine against avian influenza A (H7N9) virus

M Hasan, PP Ghosh, KF Azim, S Mukta, RA Abir… - Microbial …, 2019 - Elsevier
H7N9, a novel strain of avian origin influenza was the first recorded incidence where a
human was transited by a N9 type influenza virus. Effective vaccination against influenza A …

Immuno-informatics profiling of monkeypox virus cell surface binding protein for designing a next generation multi-valent peptide-based vaccine

M Yousaf, S Ismail, A Ullah, S Bibi - Frontiers in Immunology, 2022 - frontiersin.org
Monkeypox is a viral etiological agent with hallmarks analogous to those observed in
smallpox cases in the past. The ongoing outbreak of Monkeypox viral infection is becoming …

Multiepitope Subunit Vaccine Design against COVID‐19 Based on the Spike Protein of SARS‐CoV‐2: An In Silico Analysis

HA Dar, Y Waheed, MH Najmi, S Ismail… - Journal of …, 2020 - Wiley Online Library
The global health crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS‐
CoV‐2), the causal agent of COVID‐19, has resulted in a negative impact on human health …

In silico design of enzyme α-amylase and α-glucosidase inhibitors using molecular docking, molecular dynamic, conceptual DFT investigation and pharmacophore …

H Chenafa, F Mesli, I Daoud, R Achiri… - Journal of …, 2022 - Taylor & Francis
Type 2 diabetes mellitus (T2DM) is characterized by elevated blood glucose levels and can
lead to serious complications such as nephropathy, neuropathy, retinopathy and …