Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor
of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes …

Background Heterotopic Ossification (HO) is a common condition referring to ectopic bone
formation in soft tissues. It has two major etiologies, acquired (more common) and genetic …

Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of
the ventral pons that, due to their location within the brain, are unsuitable for surgical …

Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which
there is currently no effective treatment. Some of these tumors combine gain-of-function …

Whole-genome sequencing studies have recently identified a quarter of cases of the rare
childhood brainstem tumor diffuse intrinsic pontine glioma to harbor somatic mutations in …

Extrinsic inhibitors at sites of blood–brain barrier disruption and neurovascular damage
contribute to remyelination failure in neurological diseases. However, therapies to overcome …

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder of extraskeletal
bone formation, but could appropriately be viewed as a seminal disorder of …

Abstract Activin receptor-like kinase-2 (ALK2), the product of ACVR1, is a member of the
type I bone morphogenetic protein (BMP) receptor family. ALK2 exerts key and non …

Heterotopic ossification (HO) after hip arthroscopy is the abnormal formation of mature
lamellar bone within extra skeletal soft tissues. HO may lead to pain, impaired range of …

Substantial progress has been made in identifying the extracellular signalling pathways that
regulate neural stem and precursor cell biology in the central nervous system (CNS). The …