Simple Summary Kidney cancer is a frequent malignant tumor that accounts for
approximately 5% of all cancer incidences. It affects both males and females, but males are …

Cell cycle and apoptosis regulator 2 (CCAR2), also known as deleted in breast cancer 1
(DBC1), has been recently identified as a master regulator of transcriptional processes and …

Increasing evidence has demonstrated that the androgen receptor (AR) plays important
roles to promote the metastasis of clear cell renal cell carcinoma (ccRCC). The detailed …

A gender discrepancy exists in the incidence of both urothelial and kidney carcinomas, with
more men presenting with these cancers than women. Men have a threefold greater risk of …

Men are more frequently diagnosed with kidney cancer than women, with a more aggressive
histology, larger tumors, a higher grade and stage, and worse oncological outcomes …

Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists,
and protein kinase CK2 α1 (CSNK2A1) has been shown to be involved in tumorigenesis by …

Silent mating type information regulation 1 (SIRT1) is implicated in tumorigenesis through its
effect on autophagy. In gastric cancer (GC), SIRT1 is a marker for prognosis and is involved …

DBC1 has been characterized as a key regulator of physiological and pathophysiological
activities, such as DNA damage, senescence, and tumorigenesis. However, the mechanism …

Abstract Sirtuin1 (SIRT1) is a conserved nicotinamide adenine dinucleotide (NAD+)-
dependent histone deacetylase that plays key roles in a range of cellular events, including …

In the 1940s Charles Huggins reported remarkable palliative benefits following surgical
castration in men with advanced prostate cancer, and since then the androgen receptor (AR) …