An overview of vaccine adjuvants: current evidence and future perspectives
Vaccinations are one of the most important preventive tools against infectious diseases.
Over time, many different types of vaccines have been developed concerning the antigen …
Over time, many different types of vaccines have been developed concerning the antigen …
Amino assets: how amino acids support immunity
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …
is well defined, but they contribute to a host of other intracellular metabolic pathways …
[HTML][HTML] Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled …
Background Stalled progress in controlling Plasmodium falciparum malaria highlights the
need for an effective and deployable vaccine. RTS, S/AS01, the most effective malaria …
need for an effective and deployable vaccine. RTS, S/AS01, the most effective malaria …
RTS, S/AS01 vaccine (Mosquirix™): an overview
MB Laurens - Human vaccines & immunotherapeutics, 2020 - Taylor & Francis
Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …
Malaria vaccines: recent advances and new horizons
The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …
T cell-mediated immunity to malaria
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver
LT Wang, LS Pereira, Y Flores-Garcia, J O'Connor… - Immunity, 2020 - cell.com
Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial
M Oneko, LC Steinhardt, R Yego, RE Wiegand… - Nature Medicine, 2021 - nature.com
The radiation-attenuated Plasmodium falciparum sporozoite (PfSPZ) vaccine provides
protection against P. falciparum infection in malaria-naïve adults. Preclinical studies show …
protection against P. falciparum infection in malaria-naïve adults. Preclinical studies show …
Cytokines and chemokines in cerebral malaria pathogenesis
Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …
[HTML][HTML] Antibody feedback limits the expansion of B cell responses to malaria vaccination but drives diversification of the humoral response
Generating sufficient antibody to block infection is a key challenge for vaccines against
malaria. Here, we show that antibody titers to a key target, the repeat region of the …
malaria. Here, we show that antibody titers to a key target, the repeat region of the …