As the major etiological agent of the common cold, human rhinoviruses (HRV) cause
millions of lost working and school days annually. Moreover, clinical studies proved an …

Picornaviruses constitute one of the most relevant viral groups according to their impact on
human and animal health. Etiologic agents of a broad spectrum of illnesses with a clinical …

Abstract Human enterovirus D68 (EV-D68) is a causative agent of childhood respiratory
diseases and has now emerged as a global public health threat. Nevertheless, knowledge …

BACKGROUND: Rhinovirus-induced acute asthma is the most frequent trigger for asthma
exacerbations. OBJECTIVE: We assessed which inflammatory mediators were released …

The terms" proteolytic enzyme" and" peptidase" have been treated as synonymous, and all
proteolytic enzymes have been considered to be hydrolases (EC 3.4). However, the recent …

Infection by the mosquito-borne dengue virus causes dengue fever and the sometimes fatal
dengue hemorrhagic fever. The increasing number of dengue infections per year suggests …

Abstract Enterovirus 71 (HEV71) epidemics in children and infants result mainly in mild
symptoms; however, especially in the Asia-Pacific region, infection can be fatal. At present …

The cryo-EM structure of the human rhinovirus B14 determined in this study reveals 13-bp
RNA duplexes symmetrically bound to regions around each of the 30 two-fold axes in the …

Pleconaril, a specific inhibitor of human picornaviruses, showed therapeutic efficacy against
community-acquired colds caused by rhinoviruses in two placebo-controlled trials …

Rhinoviruses (RVs) have been linked to exacerbations of many pulmonary diseases, thus
increasing morbidity and/or mortality in subjects at risk. Unfortunately, the wide variety of RV …