Human cytomegalovirus (CMV) is a betaherpesvirus in the same family as human
herpesvirus-6 and-7. CMV is a large virus including approximately 200 proteins. CMV has …

Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

T cell immunity is central for the control of viral infections. To characterize T cell immunity,
but also for the development of vaccines, identification of exact viral T cell epitopes is …

Adaptive evolution is a key feature of T cell immunity. During acute immune responses, T
cells harboring high-affinity T cell antigen receptors (TCRs) are preferentially expanded, but …

The umbrella term 'immunosenescence'is applied to describe age-associated failing
systemic immunity and is believed to contribute to the increased incidence and severity of …

Seropositivity for CMV is one of the parameters of the “immune risk profile” associated with
mortality in longitudinal studies of the very elderly and may accelerate immunosenescence …

Attenuated poxvirus modified vaccinia Ankara (MVA) is a useful viral-based vaccine for
clinical investigation, because of its excellent safety profile and property of inducing potent …

Recombinant immunotoxins (RITs) are chimeric proteins that are being developed for
cancer treatment. We have produced RITs that contain PE38, a portion of the bacterial …

Large cytomegalovirus (CMV)-specific CD8 T-cell responses are observed in both young
and, somewhat more often, old people. Frequent CMV reactivation is thought to exhaust …

We conducted a phase I trial of allogeneic T cells sensitized in vitro against a pool of
pentadecapeptides (15-mer peptides) spanning the sequence of CMVpp65 for adoptive …