The development of paediatric medicines can be challenging since this is a diverse patient
population with specific needs. For example, the toxicity of excipients may differ in children …

Despite much progress in regulations to improve paediatric drug development, there
remains a significant need to develop better medications for children. For the design of oral …

OBJECTIVES: The objective of this study was to identify systemic diseases associated with
hyposalivation and xerostomia and develop evidence-based management …

Objective To identify the prevalence of the main oral problems present in special needs
children and to relate the underlying conditions with the clinical and demographic variables …

The aim of this systematic literature review was to evaluate which type of periodontal
preventive and therapeutic approaches presents superior outcomes in patients with Down …

We aimed to assess the effect of oral probiotics containing the Streptococcus salivarius K12
strain on the salivary level of secretory immunoglobulin A, salivation rate, and oral biofilm …

Aim To compare the oral health status of children and adolescents affected by intellectual
disabilities with their unaffected counterparts. Method Citations published in English were …

International Journal of Paediatric Dentistry 2010; 20: 235–241 Background: The aetiology
of low caries incidence in Down syndrome (DS) children is not entirely clear. Aim. To …

Purpose: The aim of the study was to find the relationship between salivary IgA (s-IgA) levels
and dental caries in children. Materials and Methods: A total of 40 children in the age group …

Down syndrome (DS) is the most common chromosomal disorder and cause of mental
retardation. First described by Esquirol in 1838, and later in 1866, this disorder was …