T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Abstract CD4+ CD25+ regulatory T cells (Tregs) are a class of CD4+ T cells with
immunosuppressive functions that play a critical role in maintaining immune homeostasis …

Abstract The cytokines interleukin-12 (IL-12) and IL-23 share a common IL-12/IL-23p40
subunit in structure and play a central role in T cell-mediated responses in inflammation …

Leprosy is a chronic bacterial disease caused by Mycobacterium leprae. Leprosy patients
have been found to have defects in T cells activation, which is critical to the clearance of the …

Regulatory T cells (Tregs) express the lineage-defining transcription factor FoxP3 and play
crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based …

Leprosy is a chronic infectious disease whose evolution involves complex immune
mechanisms of the host that influence the clinical presentation of the disease. For many …

Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical
manifestations, which are strongly correlated with the host's immune response. Skin lesions …

Abstract Lepromatous leprosy (L-LEP), caused by the massive proliferation of
Mycobacterium leprae primarily in macrophages, is an ideal disease model for investigating …

Abstract CD4+ CD25+ Foxp3+ Tregs play an important role in the maintenance of the
immune system by regulating immune responses and resolving inflammation. Tregs exert …