Examining metal contents in primary and secondhand aerosols released by electronic cigarettes

KF Kapiamba, W Hao, SY Owusu, W Liu… - Chemical Research …, 2022 - ACS Publications
The usage of electronic cigarettes (ECs) has surged since their invention two decades ago.
However, to date, the health effects of EC aerosol exposure are still not well understood …

[HTML][HTML] Multiple endpoint in vitro toxicity assessment of a prototype heated tobacco product indicates substantially reduced effects compared to those of combustible …

F Chapman, ET Sticken, R Wieczorek, SJ Pour… - Toxicology in Vitro, 2023 - Elsevier
This study aimed to compare the aerosol chemistry and in vitro toxicological profiles of two
prototype Heated Tobacco Product (p-HTP) variants to the 1R6F Reference Cigarette. In the …

Preclinical Assessment of Tobacco-Free Nicotine Pouches Demonstrates Reduced In Vitro Toxicity Compared with Tobacco Snus and Combustible Cigarette Smoke

F Yu, K Rudd, SJ Pour, E Trelles Sticken… - Applied in vitro …, 2022 - liebertpub.com
Introduction: Tobacco harm reduction (THR) represents one of the most promising public
health policies with continued product innovations crucial to making THR a reality. Tobacco …

Applying new approach methodologies to assess next-generation tobacco and nicotine products

D Thorne, D McHugh, L Simms, KM Lee… - Frontiers in …, 2024 - frontiersin.org
In vitro toxicology research has accelerated with the use of in silico, computational
approaches and human in vitro tissue systems, facilitating major improvements evaluating …

Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry

J Miller‐Holt, H Behrsing, I Crooks… - Drug testing and …, 2023 - Wiley Online Library
Abstract The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to
develop recommendations for optimal scientific and technical approaches for conducting in …

Cytotoxicity and cell injuries of flavored electronic cigarette aerosol and mainstream cigarette smoke: a comprehensive in vitro evaluation

L Wang, Y Wang, X Yang, K Duan, X Jiang, J Chen… - Toxicology letters, 2023 - Elsevier
Introduction Although electronic cigarettes (e-cigarettes) have attracted much attention due
to their claimed harm-reduction effects compared with conventional cigarettes, the adverse …

The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols

L Czekala, F Chapman, L Simms, K Rudd… - …, 2021 - academic.oup.com
In vitro (geno) toxicity assessment of electronic vapour products (EVPs), relative to
conventional cigarette, currently uses assays, including the micronucleus and Ames tests …

Toxicological assessment of particulate and metal hazards associated with vaping frequency and device age

J Jeon, Q Zhang, PS Chepaitis, R Greenwald, M Black… - Toxics, 2023 - mdpi.com
Electronic nicotine delivery systems (ENDS) aerosols are complex mixtures of chemicals,
metals, and particles that may present inhalation hazards and adverse respiratory health …

Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure …

MM Moore, I Abraham, M Ballantyne… - Alternatives to …, 2023 - journals.sagepub.com
The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to identify,
discuss and develop recommendations for optimal scientific and technical approaches for …

Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to …

F Chapman, SJ Pour, R Wieczorek… - Frontiers in …, 2023 - frontiersin.org
Tobacco harm reduction (THR) involves providing adult smokers with potentially reduced
harm modes of nicotine delivery as alternatives to smoking combustible cigarettes. Heated …