Cellular strategies for retinal repair by photoreceptor replacement

SA Jayakody, A Gonzalez-Cordero, RR Ali… - Progress in retinal and …, 2015 - Elsevier
Loss of photoreceptors due to retinal degeneration is a major cause of blindness in the
developed world. While no effective treatment is currently available, cell replacement …

Delivery strategies for treatment of age-related ocular diseases: From a biological understanding to biomaterial solutions

V Delplace, S Payne, M Shoichet - Journal of Controlled Release, 2015 - Elsevier
Age-related ocular diseases, such as age-related macular degeneration (AMD), diabetic
retinopathy, and glaucoma, result in life-long functional deficits and enormous global health …

[HTML][HTML] Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection

H Levkovitch-Verbin, O Sadan, S Vander… - … & visual science, 2010 - arvojournals.org
Purpose.: To evaluate the neuroprotective effect of intravitreal injections of neurotrophic
factors secreting mesenchymal stem cells (NTF-SCs) on the survival of retinal ganglion cells …

Human mesenchymal stem cell secretome exhibits a neuroprotective effect over in vitro retinal photoreceptor degeneration

R Usategui-Martín, K Puertas-Neyra… - … Therapy Methods & …, 2020 - cell.com
Retinal photoreceptor degeneration occurs frequently in several neurodegenerative retinal
diseases such as age-related macular degeneration, retinitis pigmentosa, or genetic retinal …

[HTML][HTML] Transplanted mouse embryonic stem cell–derived retinal ganglion cells integrate and form synapses in a retinal ganglion cell-depleted mouse model

YR Wu, T Hashiguchi, J Sho, SH Chiou… - … & Visual Science, 2021 - jov.arvojournals.org
Purpose: Retinal ganglion cell (RGC) transplantation is a therapeutic approach to replace
irreversibly degenerated RGCs in diseases such as glaucoma. However, the application of …

Cell transplantation strategies for retinal repair

EL West, RA Pearson, RE MacLaren, JC Sowden… - Progress in brain …, 2009 - Elsevier
Cell transplantation is a novel therapeutic strategy to restore visual responses to the
degenerate adult neural retina and represents an exciting area of regenerative …

Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve

A Dahlmann-Noor, S Vijay, H Jayaram, A Limb… - Canadian Journal of …, 2010 - Elsevier
The 3 most common causes of visual impairment and legal blindness in developed
countries (age-related macular degeneration, glaucoma, and diabetic retinopathy) share 1 …

Concise review: toward stem cell-based therapies for retinal neurodegenerative diseases

ND Bull, KR Martin - Stem cells, 2011 - academic.oup.com
Loss of sight due to irreversible retinal neurodegeneration imposes a significant disease
burden on both patients and society. Glaucoma and age-related macular degeneration are …

Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies

AH Dahlmann-Noor, S Vijay, GA Limb, PT Khaw - Drug discovery today, 2010 - Elsevier
Glaucoma is the most common age-related optic nerve disease and also the most common
neuropathy, affecting∼ 60 million people worldwide in its most common forms. This figure is …

Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases

K Puertas-Neyra, R Usategui-Martín… - Neural regeneration …, 2020 - journals.lww.com
Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many
pathologies included under this umbrella involve progressive degeneration and ultimate …