Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Inflammogenesis of secondary spinal cord injury

MA Anwar, TS Al Shehabi, AH Eid - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Spinal cord injury (SCI) and spinal infarction lead to neurological complications and
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …

Animal models of spinal cord injury: a systematic review

M Sharif-Alhoseini, M Khormali, M Rezaei, M Safdarian… - Spinal cord, 2017 - nature.com
Study Design: PRISMA-guided systematic review. Objectives: To provide a comprehensive
framework of the current animal models for investigating spinal cord injury (SCI) and …

Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives

JCT Chio, KJ Xu, P Popovich, S David… - Experimental …, 2021 - Elsevier
Spinal cord injury (SCI) has a complex pathophysiology. Following the initial physical
trauma to the spinal cord, which may cause vascular disruption, hemorrhage, mechanical …

Diversity of reactive astrogliosis in CNS pathology: heterogeneity or plasticity?

AJ Moulson, JW Squair, RJM Franklin… - Frontiers in cellular …, 2021 - frontiersin.org
Astrocytes are essential for the development and homeostatic maintenance of the central
nervous system (CNS). They are also critical players in the CNS injury response during …

Function and mechanisms of autophagy in brain and spinal cord trauma

MM Lipinski, J Wu, AI Faden, C Sarkar - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Traumatic brain injury (TBI) and spinal cord injury (SCI) are major causes of
death and long-term disability worldwide. Despite important pathophysiological differences …

Neuronal redevelopment and the regeneration of neuromodulatory axons in the adult mammalian central nervous system

P Cooke, H Janowitz, SE Dougherty - Frontiers in cellular …, 2022 - frontiersin.org
One reason that many central nervous system injuries, including those arising from traumatic
brain injury, spinal cord injury, and stroke, have limited recovery of function is that neurons …

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

M Capogrosso, FB Wagner, J Gandar, EM Moraud… - Nature …, 2018 - nature.com
Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait
kinematics are powerful methods for the study of locomotion and the improvement of motor …

Endogenous neural stem cell responses to stroke and spinal cord injury

CA Grégoire, BL Goldenstein, EM Floriddia… - Glia, 2015 - Wiley Online Library
Stroke and spinal cord injury (SCI) are among the most frequent causes of central nervous
system (CNS) dysfunction, affecting millions of people worldwide each year. The personal …

Human epidural AD–MSC exosomes improve function recovery after spinal cord injury in rats

SE Sung, MS Seo, YI Kim, KK Kang, JH Choi, S Lee… - Biomedicines, 2022 - mdpi.com
Spinal cord injury (SCI) interferes with the normal function of the autonomic nervous system
by blocking circuits between the sensory and motor nerves. Although many studies focus on …