Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a
paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation …

Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …

The transition of AKI to CKD has major clinical significance. As reviewed here, recent studies
show that a subpopulation of dedifferentiated, proliferating tubules recovering from AKI …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected. Although
AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very …

The current view of diabetic kidney disease, based on meticulously acquired ultrastructural
morphometry and the utility of measuring plasma creatinine and urinary albumin, has been …

During recovery by regeneration after AKI, proximal tubule cells can fail to redifferentiate,
undergo premature growth arrest, and become atrophic. The atrophic tubules display …

Fibrosis of the glomerular and tubulointerstitial compartments is a common feature of chronic
kidney disease leading to end-stage renal failure. This fibrotic process involves a number of …

Renal fibrosis is the final, common pathway of end-stage renal disease. Whether and how
autophagy contributes to renal fibrosis remains unclear. Here we first detected persistent …