Abstract 293 cell line (widely known as the Human Embryonic Kidney 293 cells) and its
derivatives were the most used cells after HeLa in cell biology studies and after CHO in …

Recently, non-clonal chromosomal alterations previously unappreciated are being proposed
to be included in cytogenetic practice. The aim of this inclusion is to obtain a greater …

Current cytogenetics has largely focused its efforts on the identification of recurrent
karyotypic alterations, also known as clonal chromosomal aberrations (CCAs). The rationale …

Background The genetic basis of metastasis is still unclear because metastases carry
individual karyotypes and phenotypes, rather than consistent mutations, and are rare …

Cancer is a disease of cellular evolution. For this cellular evolution to take place, a
population of cells must contain functional heterogeneity and an assessment of this …

The pattern of genome evolution can be divided into two phases: the step-wise continuous
phase (step-wise clonal evolution, stable dominant clonal chromosome aberrations (CCAs) …

Uniparental disomy (UPD) is a topic, which normally is considered to be something
molecular genetics has to take care of exclusively. As UPD is characterized by microsatellite …

Trophoblastic cell lines are established models used to examine human placenta
physiology and disease. We performed concurrent cytogenetic analyses of six established …

It has been known for over 100 years that cancers have individual karyotypes and arise only
years to decades after initiating carcinogens. However, there is still no coherent theory to …

Background Despite over 50 years of research, it remains unclear how the DNA tumor
viruses SV40 and Polyoma cause cancers. Prevailing theories hold that virus-coded Tumor …