Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

Recent studies have deepened our understanding of multiple mechanisms by which
extracellular matrix (ECM) molecules regulate various aspects of synaptic plasticity and …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Coping with stress is fundamental for mental health, but understanding of the molecular
neurobiology of stress is still in its infancy. Adult neurogenesis is well known to be regulated …

Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …

Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk
factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have …

Recently higher rates of autism diagnosis suggest involvement of environmental factors in
causing this developmental disorder, in concert with genetic risk factors. Autistic children …

Reelin, an extracellular protein essential for neural migration and lamination, is also
expressed in the adult brain. To unravel the function of this protein in the adult forebrain, we …

One of the exceptional properties of the brain is its ability to acquire new knowledge through
learning and to store that information through memory. The epigenetic mechanisms linking …

Apolipoprotein receptors belong to an evolutionarily conserved surface receptor family that
has intimate roles in the modulation of synaptic plasticity and is necessary for proper …