Alzheimer's disease (AD) has become a major disease contributing to human death and is
thought to be closely related to the aging process. The rich antioxidant substances in plants …

Senescence accelerated mice P8 (SAMP8) show significant age‐related deteriorations in
memory and learning ability in accordance with early onset and rapid advancement of …

Microglia most likely appeared early in evolution as they are not only present in vertebrates,
but are also found in nervous systems of various nonvertebrate organisms. Mammalian …

Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …

Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder
characterized by widespread oligodendroglial cytoplasmic inclusions of filamentous α …

Microglia constitute the brain's immunocompetent cells and are intricately implicated in
numerous inflammatory processes included in neonatal brain injury. In addition, clearance …

In this review, we summarize key observations supporting the idea of immunosenescence in
the CNS. We provide a discussion of senescent changes that affect microglial cells and …

Alzheimer's disease (AD) is a progressive and neurodegenerative disorder that induces
dementia in older people. It was first reported in 1907 by Alois Alzheimer, who characterized …

Parkinson's disease is one of the most common neurodegenerative disorders of the elderly
and ageing hence described to be a major risk factor. Telomere shortening as a result of the …

The most common dementias such as Alzheimer's disease, vascular dementia, Lewy body
dementia, and frontotemporal dementia are associated with a decline in cognitive and social …