Calcium ion (Ca 2+) is a ubiquitous and versatile signaling molecule controlling a wide
variety of cellular processes, such as proliferation, cell death, migration, and immune …

Lead (Pb) exposure remains a pressing concern in the realm of public health, with a
mounting body of evidence underscoring its adverse impact on cardiovascular well-being …

Darier disease (DD) is a rare, inherited multi-organ disorder associated with mutations in the
ATP2A2 gene. DD patients often have skin involvement characterized by malodorous …

The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely
unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows …

Introduction B-cell activation triggers the release of endoplasmic reticulum calcium stores
through the store-operated calcium entry (SOCE) pathway resulting in calcium influx by …

Calcium ions (Ca2+) play a crucial role as secondary messengers in both excitable and non-
excitable cells. A complex system of proteins and molecules involved in calcium handling …

The well-known insulin-like growth factor 1 (IGF1)/IGF-1 receptor (IGF-1R) signaling
pathway is overexpressed in many tumors, and is thus an attractive target for cancer …

Ethnopharmacological relevance The pathogenesis of alcoholic gastric injury has long been
a significant topic in the medical field. Dan-Shen-Yin (DSY), a classic traditional Chinese …

PBX1 is a transcription factor that can promote the occurrence of various tumors and play a
reg-ulatory role in tumor growth, metastasis, invasion, and drug resistance. Furthermore, a …

Darier disease is a rare autosomal dominant genodermatosis caused by mutations in the
ATP2A2 gene encoding for sarcoendoplasmic reticulum Ca2+ ATPase isoform 2. The skin …