[HTML][HTML] Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework
Z Sarnyai, D Ben-Shachar - Psychiatry Research, 2024 - Elsevier
Schizophrenia is a chronic, neurodevelopmental disorder with unknown aetiology and
pathophysiology that emphasises the role of neurotransmitter imbalance and abnormalities …
pathophysiology that emphasises the role of neurotransmitter imbalance and abnormalities …
The Poly I: C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats
M Casquero-Veiga, N Lamanna-Rama… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction: Prenatal infections are associated with an increased risk of the onset of
schizophrenia. Rodent models of maternal immune stimulation (MIS) have been extensively …
schizophrenia. Rodent models of maternal immune stimulation (MIS) have been extensively …
[HTML][HTML] Maternal infection during pregnancy aggravates the behavioral response to an immune challenge during adolescence in female rats
CGJ Guerrin, EFJ de Vries, K Prasad… - Behavioural Brain …, 2023 - Elsevier
Prenatal and early postnatal infection have been associated with changes in microglial
activity and the development of psychiatric disorders. Here, we investigated the effect of …
activity and the development of psychiatric disorders. Here, we investigated the effect of …
[HTML][HTML] Maternal immune activation and estrogen receptor modulation induce sex-specific dopamine-related behavioural and molecular alterations in adult rat …
SR Debs, I Conn, B Navaneethan, AG Penklis… - Brain, Behavior, and …, 2024 - Elsevier
Dopamine dysregulation contributes to psychosis and cognitive deficits in schizophrenia that
can be modelled in rodents by inducing maternal immune activation (MIA). The selective …
can be modelled in rodents by inducing maternal immune activation (MIA). The selective …
Maternal immune activation induces sex-dependent behavioral differences in a rat model of schizophrenia
Y Liu, X Hang, Y Zhang, Y Fang, S Yuan… - Frontiers in …, 2024 - frontiersin.org
Background Maternal immune activation (MIA) is a mature means to construct a
schizophrenia model. However, some preclinical studies have reported that a MIA-induced …
schizophrenia model. However, some preclinical studies have reported that a MIA-induced …
[HTML][HTML] Maternal choline supplementation modulates cognition and induces anti-inflammatory signaling in the prefrontal cortices of adolescent rats exposed to …
C King, B Plakke - Brain, Behavior, & Immunity-Health, 2024 - Elsevier
Maternal infection has long been described as a risk factor for neurodevelopmental
disorders, especially autism spectrum disorders (ASD) and schizophrenia. Although many …
disorders, especially autism spectrum disorders (ASD) and schizophrenia. Although many …
Behavioural consequences of maternal stressors in a rat model for schizophrenia
JM Lorusso - 2023 - search.proquest.com
Schizophrenia is a neurodevelopmental disorder defined by posiive (eg hallucinaions) and
negaive symptoms (eg social withdrawal) as well as cogniive dysfuncion. Schizophrenia risk …
negaive symptoms (eg social withdrawal) as well as cogniive dysfuncion. Schizophrenia risk …
The dual hit hypothesis of schizophrenia
C Guerrin - 2023 - research.rug.nl
Schizophrenia, a complex psychiatric disorder, significantly affects social and professional
life. It typically emerges in early adulthood, and its symptomatology is classified into positive …
life. It typically emerges in early adulthood, and its symptomatology is classified into positive …