Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts
multiple intracellular signalling cascades. Recent studies in three general areas have …

Immune cell activation is a stringently regulated process, as exaggerated innate and
adaptive immune responses can lead to autoinflammatory and autoimmune diseases …

Systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and Sjögren's
syndrome are four major autoimmune rheumatic diseases characterized by the presence of …

Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized
by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3 …

Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune
system and connective tissue. SSc stands out as a severely incapacitating and life …

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and
organ fibrosis. The pathogenesis of SSc and its progression are poorly understood. The SSc …

With unknown etiology, scleroderma (SSc) is a multifaceted disease characterized by
immune activation, vascular complications, and excessive fibrosis in internal organs …

Systemic sclerosis (SSc or scleroderma) is a progressive and highly debilitating
autoimmune disorder characterized by inflammation, vasculopathy, and extensive fibrosis …

Functional characterization of causal variants present on risk haplotypes identified through
genome-wide association studies (GWAS) is a primary objective of human genetics. In this …