Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the synthesis of
monounsaturated fatty acids, mainly oleate (18: 1) and palmitoleate (16: 1). These represent …

Fluorescence polarization holds considerable promise for bioanalytical systems because it
allows the detection of selective interactions in real time and a choice of fluorophores, the …

Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is
required for the biosynthesis of oleate (18: 1) and palmitoleate (16: 1). These …

▪ Abstract Atherosclerosis, the primary cause of coronary artery disease (CAD) and stroke, is
a disorder with multiple genetic and environmental contributions. Genetic-epidemiologic …

Geneticists have repeatedly turned to population isolates for mapping and cloning
Mendelian disease genes. Population isolates possess many advantages in this regard …

Stearoyl-CoA desaturase (SCD)(EC 1.14. 99.5) is an endoplasmic reticulum-bound enzyme
that catalyzes the Δ9-cis desaturation of saturated fatty acyl-CoAs, the preferred substrates …

The availability of plastic microspheres labeled with different-emitting isotopes has allowed
the quantification of blood flow in different organs, including the heart (1). In the past 3 …

Genetic isolates, as shown empirically by the Finnish, Old Order Amish, Hutterites, Sardinian
and Jewish communities among others, represent a most important and powerful tool in …

In the minisequencing primer extension reaction, a DNA polymerase is used specifically to
extend a primer that anneals immediately adjacent to the nucleotide position to be analyzed …

Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total
cholesterol, triglycerides or both,, is observed in about 20% of individuals with premature …