A beginner's guide to eukaryotic genome annotation

M Yandell, D Ence - Nature Reviews Genetics, 2012 - nature.com
The falling cost of genome sequencing is having a marked impact on the research
community with respect to which genomes are sequenced and how and where they are …

VDAC, a multi-functional mitochondrial protein regulating cell life and death

V Shoshan-Barmatz, V De Pinto, M Zweckstetter… - Molecular aspects of …, 2010 - Elsevier
Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Genetics on the Fly: A Primer on the Drosophila Model System

KG Hales, CA Korey, AM Larracuente, DM Roberts - Genetics, 2015 - academic.oup.com
Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

Diversity and dynamics of the Drosophila transcriptome

JB Brown, N Boley, R Eisman, GE May, MH Stoiber… - Nature, 2014 - nature.com
Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …

Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments

BJ Haas, SL Salzberg, W Zhu, M Pertea, JE Allen… - Genome biology, 2008 - Springer
EVidenceModeler (EVM) is presented as an automated eukaryotic gene structure annotation
tool that reports eukaryotic gene structures as a weighted consensus of all available …

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

University of Utah Weiss Robert B. 14 Dunn Diane M … - Nature, 2004 - nature.com
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine
and drug development, having made inestimable contributions to human health. We report …

The molecular basis of insecticide resistance in mosquitoes

J Hemingway, NJ Hawkes, L McCarroll… - Insect biochemistry and …, 2004 - Elsevier
Insecticide resistance is an inherited characteristic involving changes in one or more insect
gene. The molecular basis of these changes are only now being fully determined, aided by …

A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes

EV Koonin, ND Fedorova, JD Jackson, AR Jacobs… - Genome biology, 2004 - Springer
Background Sequencing the genomes of multiple, taxonomically diverse eukaryotes
enables in-depth comparative-genomic analysis which is expected to help in reconstructing …

Insect genomes: progress and challenges

F Li, X Zhao, M Li, K He, C Huang, Y Zhou… - Insect molecular …, 2019 - Wiley Online Library
In the wake of constant improvements in sequencing technologies, numerous insect
genomes have been sequenced. Currently, 1219 insect genome‐sequencing projects have …

Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster

HM Robertson, CG Warr… - Proceedings of the …, 2003 - National Acad Sciences
The insect chemoreceptor superfamily in Drosophila melanogaster is predicted to consist of
62 odorant receptor (Or) and 68 gustatory receptor (Gr) proteins, encoded by families of 60 …