Patient-centred approaches for the management of unpleasant symptoms in kidney disease

K Kalantar-Zadeh, MB Lockwood, CM Rhee… - Nature Reviews …, 2022 - nature.com
Patients with chronic kidney disease (CKD) frequently experience unpleasant symptoms.
These can be gastrointestinal (constipation, nausea, vomiting and diarrhoea), psychological …

Intestinal microbiome and fitness in kidney disease

B Meijers, P Evenepoel, HJ Anders - Nature reviews nephrology, 2019 - nature.com
Environmental changes can induce diversity shifts within ecosystems that affect interactions
between species. Similarly, the development of kidney disease induces shifts within the …

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

K Kikuchi, D Saigusa, Y Kanemitsu… - Nature …, 2019 - nature.com
Diabetic kidney disease is a major cause of renal failure that urgently necessitates a
breakthrough in disease management. Here we show using untargeted metabolomics that …

Lipotoxicity in kidney, heart, and skeletal muscle dysfunction

H Nishi, T Higashihara, R Inagi - Nutrients, 2019 - mdpi.com
Dyslipidemia is a common nutritional and metabolic disorder in patients with chronic kidney
disease. Accumulating evidence supports the hypothesis that prolonged metabolic …

Impact of altered intestinal microbiota on chronic kidney disease progression

E Castillo-Rodriguez, R Fernandez-Prado, R Esteras… - Toxins, 2018 - mdpi.com
In chronic kidney disease (CKD), accumulation of uremic toxins is associated with an
increased risk of CKD progression. Some uremic toxins result from nutrient processing by …

A randomized trial of magnesium oxide and oral carbon adsorbent for coronary artery calcification in predialysis CKD

Y Sakaguchi, T Hamano, Y Obi, C Monden… - Journal of the …, 2019 - journals.lww.com
Background Developing strategies for managing coronary artery calcification (CAC) in
patients with CKD is an important clinical challenge. Experimental studies have …

Uraemic solutes as therapeutic targets in CKD-associated cardiovascular disease

JD Ravid, MH Kamel, VC Chitalia - Nature Reviews Nephrology, 2021 - nature.com
Chronic kidney disease (CKD) is characterized by the retention of a myriad of solutes termed
uraemic (or uremic) toxins, which inflict damage to several organs, including the …

Cardiotoxicity of uremic toxins: a driver of cardiorenal syndrome

S Lekawanvijit - Toxins, 2018 - mdpi.com
Cardiovascular disease (CVD) is highly prevalent in the setting of chronic kidney disease
(CKD). Such coexistence of CVD and CKD—the so-called “cardiorenal or renocardiac …

The gut microbiota and its relationship with chronic kidney disease

C Plata, C Cruz, LG Cervantes, V Ramirez - International Urology and …, 2019 - Springer
Chronic kidney disease (CKD) is a worldwide health problem, because it is one of the most
common complications of metabolic diseases including obesity and type 2 diabetes …

Uremic toxic blood-brain barrier disruption mediated by AhR activation leads to cognitive impairment during experimental renal dysfunction

M Bobot, L Thomas, A Moyon… - Journal of the …, 2020 - journals.lww.com
Background Uremic toxicity may play a role in the elevated risk of developing cognitive
impairment found among patients with CKD. Some uremic toxins, like indoxyl sulfate, are …