Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia
S Beneyto-Calabuig, AK Merbach, JA Kniffka, M Antes… - Cell Stem Cell, 2023 - cell.com
Inter-patient variability and the similarity of healthy and leukemic stem cells (LSCs) have
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …
Clonal haematopoiesis, ageing and kidney disease
Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a
sizeable proportion of an individual's circulating blood cells are derived from a single …
sizeable proportion of an individual's circulating blood cells are derived from a single …
Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis
W Liu, M Yalcinkaya, IF Maestre, M Olszewska… - Nature cardiovascular …, 2023 - nature.com
Clonal hematopoiesis (CH) increases the risk of atherosclerotic cardiovascular disease
possibly due to increased plaque inflammation. Human studies suggest that limitation of …
possibly due to increased plaque inflammation. Human studies suggest that limitation of …
Somatic TET2 Mutations are Associated with Giant Cell Arteritis
Objective Giant cell arteritis (GCA) is an age-related vasculitis. Prior studies have identified
an association between GCA and hematologic malignancies (HM). How the presence of …
an association between GCA and hematologic malignancies (HM). How the presence of …
Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu's arteritis, ANCA-associated vasculitis and giant cell arteritis
F Gutierrez-Rodrigues, KV Wells, AI Jones… - Annals of the …, 2024 - ard.bmj.com
Objectives Ageing and inflammation are associated with clonal haematopoiesis (CH), the
emergence of somatic mutations in haematopoietic cells. This study details CH in patients …
emergence of somatic mutations in haematopoietic cells. This study details CH in patients …
Invasive Assessment of Coronary Artery Disease in Clonal Hematopoiesis of Indeterminate Potential
JB Heimlich, MA Raddatz, J Wells… - Circulation: Genomic …, 2024 - ahajournals.org
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) occurs due to
acquired mutations in bone marrow progenitor cells. CHIP confers a 2-fold risk of …
acquired mutations in bone marrow progenitor cells. CHIP confers a 2-fold risk of …
[PDF][PDF] Association of Somatic TET2 Mutations With Giant Cell Arteritis
Objective. Giant cell arteritis (GCA) is an age-related vasculitis. Prior studies have identified
an association between GCA and hematologic malignancies (HMs). How the presence of …
an association between GCA and hematologic malignancies (HMs). How the presence of …