Retinitis Pigmentosa (RP) is a hereditary retinopathy that affects about 2.5 million people
worldwide. It is characterized with progressive loss of rods and cones and causes severe …

Artificial nerve guide conduits have the advantage over autografts in terms of their
availability and ease of fabrication. However, clinical outcomes associated with the use of …

Background: The vascular complications of diabetes mellitus are the major causes of
morbidity and mortality among people with diabetes. Circular RNAs are a class of …

Purpose.: Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in
transducing inner retinal neurons after intravitreal injection in several species. However …

In glaucoma, the major cause of global irreversible blindness, there is an urgent need for
treatment modalities that directly target the RGCs. The discovery of an alternative …

A variety of neurotrophic factors have been used in attempts to improve morphological and
behavioural outcomes after experimental spinal cord injury (SCI). Here we review many of …

The optic nerve crush injury is a well-accepted model to study the mechanisms of axonal
regeneration after trauma in the CNS. The infection of retinal ganglion cells (RGCs) with an …

This review will describe the unique advantages that are offered by the visual system of
mammals and other vertebrates for studying the regenerative responses of the central …

We examined in adult Sprague Dawley rats the loss of retinal ganglion cells (RGCs) induced
by complete intraorbital optic nerve crush (IONC) as well as the effects of several …

Recombinant adeno-associated virus (rAAV) vectors are increasingly being used as tools for
gene therapy, and clinical trials have begun in patients with genetically linked retinal …