The self-obsession of T cells: how TCR signaling thresholds affect fate'decisions' and effector function
KA Hogquist, SC Jameson - Nature immunology, 2014 - nature.com
Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by
clonal selection to protect the host from autoimmune pathology. It is now understood that the …
clonal selection to protect the host from autoimmune pathology. It is now understood that the …
Positive-selection-inducing self-peptides displayed by cortical thymic epithelial cells
K Takada, Y Takahama - Advances in immunology, 2015 - Elsevier
A repertoire of antigen recognition specificities in mature T cell pool is formed by the
selection during T cell development in the thymus. Positive selection is an essential process …
selection during T cell development in the thymus. Positive selection is an essential process …
Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination
Self–non-self discrimination is central to T cell-mediated immunity. The kinetic proofreading
model can explain T cell antigen receptor (TCR) ligand discrimination; however, the rate …
model can explain T cell antigen receptor (TCR) ligand discrimination; however, the rate …
Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding
PE Chappell, EK Meziane, M Harrison, Ł Magiera… - elife, 2015 - elifesciences.org
Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of
adaptive immune responses, playing crucial roles in many kinds of disease and in …
adaptive immune responses, playing crucial roles in many kinds of disease and in …
In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
Individuals with narcolepsy suffer from abnormal sleep patterns due to loss of neurons that
uniquely supply hypocretin (HCRT). Previous studies found associations of narcolepsy with …
uniquely supply hypocretin (HCRT). Previous studies found associations of narcolepsy with …
Changing the peptide specificity of a human T-cell receptor by directed evolution
Binding of a T-cell receptor (TCR) to a peptide/major histocompatibility complex is the key
interaction involved in antigen specificity of T cells. The recognition involves up to six …
interaction involved in antigen specificity of T cells. The recognition involves up to six …
Indoctrinating T cells to attack pathogens through homeschooling
CS Parello, ES Huseby - Trends in immunology, 2015 - cell.com
Adaptive immunity is predicated on the ability of the T cell repertoire to have pre-existing
specificity for the universe of potential pathogens. Recent findings suggest that T cell …
specificity for the universe of potential pathogens. Recent findings suggest that T cell …
Novel Modules in the T Cell Signaling Circuit Which Enable Synergy between Responses to Self and Foreign Peptides
G Wolf - 2022 - search.proquest.com
T cell activation occurs when a T cell receptor (TCR) engages with cognate agonistic
peptides in the context of Major Histocompatibility Complexes (pMHCs) on antigen …
peptides in the context of Major Histocompatibility Complexes (pMHCs) on antigen …
Impact of Time on the Size, Shape and Effector Responses of Cd4⁺ T Cells
NR Deshpande - 2015 - repository.arizona.edu
T cells discriminate self from foreign peptides presented in the context of self-major
histocompatibility complex (pMHC) molecules via clonotypic T cell receptors (TCRs). CD8⁺ …
histocompatibility complex (pMHC) molecules via clonotypic T cell receptors (TCRs). CD8⁺ …
Compositions and methods for diagnosing narcolepsy
W Jiang, E Mellins - US Patent App. 17/414,829, 2023 - Google Patents
2021-12-21 Assigned to THE BOARD OF TRUSTEES OF THE LELAND STANFORD
JUNIOR UNIVERSITY reassignment THE BOARD OF TRUSTEES OF THE LELAND …
JUNIOR UNIVERSITY reassignment THE BOARD OF TRUSTEES OF THE LELAND …