The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

Metformin is a first-line drug for treating type 2 diabetes mellitus (T2DM) and one of the most
commonly prescribed drugs in the world. Besides its hypoglycemic effects, metformin also …

Epilepsy is a chronic neurological disease characterized by recurrent seizures. Epilepsy is
observed as a well‐controlled disease by anti‐epileptic agents (AEAs) in about 69 …

Background The comorbidity between diabetes mellitus and depression was revealed, and
diabetes mellitus increased the prevalence of depressive disorder, which ranked 13th in the …

Background Emerging evidence showed metformin may have pleiotropic effects on
ameliorating depression. However, whether metformin was associated with decreased risk …

Diabetic patients are more affected by depression than non-diabetics, and this is related to
greater treatment resistance and associated with poorer outcomes. This increase in the …

Diabetes mellitus (DM) is a metabolic disease that activates several molecular pathways
involved in neurodegenerative disorders. Metformin, an anti-hyperglycemic drug used for …

Parkinson's disease (PD) remains a disease of little known etiology. In addition to the motor
symptoms, depression is present in about 40% of patients, contributing to the loss of quality …

Mounting evidence links obesity, metabolic dysfunction, mood, and cognition. Compromised
metabolic health and psychological functioning worsen clinical outcomes, diminish quality of …

Allergic rhinitis (AR) is a widespread disease that is frequently comorbid with depression.
However, the mechanisms and treatments for depression in AR remain underexplored …