Glycosylation is a well-regulated cell and microenvironment specific post-translational modification. Several glycosyltransferases and glycosidases orchestrate the addition of …
Tumour growth is accompanied by tumour evasion of the immune system, a process that is facilitated by immune checkpoint molecules such as programmed cell death protein 1 (PD1) …
S Esmail, MF Manolson - European journal of cell biology, 2021 - Elsevier
N-linked glycosylation is a post-translational modification crucial for membrane protein folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …
J Namkung - Journal of Microbiology, 2020 - Springer
Researches on the microbiome have been actively conducted worldwide and the results have shown human gut bacterial environment significantly impacts on immune system …
GE Cervoni, JJ Cheng, KA Stackhouse… - Biochemical …, 2020 - portlandpress.com
Protein glycosylation represents a nearly ubiquitous post-translational modification, and altered glycosylation can result in clinically significant pathological consequences. Here we …
JM Burchell, R Beatson, R Graham… - Biochemical Society …, 2018 - portlandpress.com
Changes in mucin-type O-linked glycosylation are seen in over 90% of breast cancers where increased sialylation is often observed and a change from branched glycans to linear …
R Beatson, R Graham, F Grundland Freile… - Communications …, 2020 - nature.com
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor …
SA Dusoswa, J Verhoeff, E Abels… - Proceedings of the …, 2020 - National Acad Sciences
Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor …
M Pucci, M Duca, N Malagolini, F Dall'Olio - Cancers, 2022 - mdpi.com
Simple Summary Cancer-associated glycosylation changes are widely used as biomarkers and strongly impact malignancy. However, the clinical significance of the deranged …