Amyloidoses are a spectrum of disorders caused by abnormal folding and extracellular
deposition of proteins. The deposits lead to tissue damage and organ dysfunction …

Leukocyte cell-derived chemotaxin-2 (LECT2, also named ChM-II), initially identified as a
chemokine mediating neutrophil migration, is a multifunctional secreted factor involved in …

Yakutia, Sakha Republic, in the Siberian Far East, represents one of the coldest places on
Earth, with winter record temperatures dropping below− 70° C. Nevertheless, Yakutian …

Renal amyloid deposits can often be seen in primary amyloidosis (immunoglobulin light
chain disease) or in secondary forms such as reactive amyloidosis as well as in several …

To clarify molecular mechanisms underlying liver carcinogenesis induced by aberrant
activation of Wnt pathway, we isolated the target genes of β‐catenin from mice exhibiting …

Leukocyte cell-derived chemotaxin 2 (LECT2) is a multifunctional cytokine that especially
plays an important role in innate immune. However, the roles of LECT2 in the immune …

Using laser microdissection and mass spectrometry (MS)-based proteomics, we subtyped
amyloid deposits from 130 cases of hepatic amyloidosis. Although we confirmed that …

Amyloidosis derived from leukocyte cell–derived chemotaxin 2 is a recently recognized form
of amyloidosis, and it has already been established as a frequent form of systemic …

Amyloidosis is an uncommon disease that is characterized by abnormal extracellular
deposition of misfolded protein fibrils leading to organ dysfunction. The deposited proteins …

LECT2 (leucocyte cell‐derived chemotaxin 2) is a 16‐kDa protein mainly produced by
hepatocytes. It was first isolated in PHA‐activated human T‐cell leukaemia SKW‐3 cells and …