Advanced glycation end products and oxidative stress in type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a very complex and multifactorial metabolic disease
characterized by insulin resistance and β cell failure leading to elevated blood glucose …
characterized by insulin resistance and β cell failure leading to elevated blood glucose …
Mechanisms of diabetic complications
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …
required, but also for its major complications, affecting both small and large blood vessels …
Processed foods drive intestinal barrier permeability and microvascular diseases
Intake of processed foods has increased markedly over the past decades, coinciding with
increased microvascular diseases such as chronic kidney disease (CKD) and diabetes …
increased microvascular diseases such as chronic kidney disease (CKD) and diabetes …
Advanced glycation endproducts in food and their effects on health
MW Poulsen, RV Hedegaard, JM Andersen… - Food and Chemical …, 2013 - Elsevier
Advanced glycation endproducts (AGEs) form by Maillard-reactions after initial binding of
aldehydes with amines or amides in heated foods or in living organisms. The mechanisms of …
aldehydes with amines or amides in heated foods or in living organisms. The mechanisms of …
Advanced glycation end products (AGE) and diabetes: cause, effect, or both?
H Vlassara, J Uribarri - Current diabetes reports, 2014 - Springer
Despite new and effective drug therapies, insulin resistance (IR), type 2 diabetes mellitus
(T2D) and its complications remain major medical challenges. It is accepted that IR, often …
(T2D) and its complications remain major medical challenges. It is accepted that IR, often …
Senescence in wound repair: emerging strategies to target chronic healing wounds
HN Wilkinson, MJ Hardman - Frontiers in cell and developmental …, 2020 - frontiersin.org
Cellular senescence is a fundamental stress response that restrains tumour formation. Yet,
senescence cells are also present in non-cancerous states, accumulating exponentially with …
senescence cells are also present in non-cancerous states, accumulating exponentially with …
Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1
W Cai, M Ramdas, L Zhu, X Chen… - Proceedings of the …, 2012 - National Acad Sciences
The epidemics of insulin resistance (IR) and type 2 diabetes (T2D) affect the first world as
well as less-developed countries, and now affect children as well. Persistently elevated …
well as less-developed countries, and now affect children as well. Persistently elevated …
The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions
M Bensellam, DR Laybutt, JC Jonas - Molecular and cellular endocrinology, 2012 - Elsevier
It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …
Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?
Since the 1980s, chronic kidney disease (CKD) affecting all ages has increased by almost
25%. This increase may be partially attributable to lifestyle changes and increased global …
25%. This increase may be partially attributable to lifestyle changes and increased global …
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress
In type 2 diabetes, hyperglycemia is present when an increased demand for insulin, typically
due to insulin resistance, is not met as a result of progressive pancreatic beta cell …
due to insulin resistance, is not met as a result of progressive pancreatic beta cell …