Regulation of head and neck squamous cancer stem cells by PI3K and SOX2

SB Keysar, PN Le, B Miller, BC Jackson… - Journal of the …, 2017 - academic.oup.com
Background: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy,
resulting in considerable undertreatment or overtreatment. New insights into the role of …

Accuracy of minimal residual disease detection by circulating tumor DNA profiling in lung cancer: a meta-analysis

R Zhong, R Gao, W Fu, C Li, Z Huo, Y Gao, Y Lu, F Li… - BMC medicine, 2023 - Springer
Background The sensitivity and specificity of minimal residual disease detected by
circulating tumor DNA profiling (ctDNA MRD) in lung cancer, with particular attention to the …

Development of a RNA-Seq based prognostic signature in lung adenocarcinoma

S Shukla, JR Evans, R Malik, FY Feng… - JNCI: Journal of the …, 2017 - academic.oup.com
Background Precision therapy for lung cancer will require comprehensive genomic testing to
identify actionable targets as well as ascertain disease prognosis. RNA-seq is a robust …

The impact of adjuvant EGFR-TKIs and 14-gene molecular assay on stage I non–small cell lung cancer with sensitive EGFR mutations

Y Jiang, Y Lin, W Fu, Q He, H Liang, R Zhong… - …, 2023 - thelancet.com
Background Currently, the role of EGFR-TKIs as adjuvant therapy for stage I, especially IA
NSCLC, after surgical resection remains unclear. We aimed to compare the effect of …

Validation of a proliferation-based expression signature as prognostic marker in early stage lung adenocarcinoma

II Wistuba, C Behrens, F Lombardi, S Wagner… - Clinical Cancer …, 2013 - AACR
Purpose: New prognostic markers to guide treatment decisions in early stage non–small cell
lung cancer are necessary to improve patient outcomes. In this report, we assess the utility of …

Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden

VE Wang, A Urisman, L Albacker, S Ali, V Miller… - … for immunotherapy of …, 2017 - Springer
Background Large cell neuroendocrine tumor (LCNEC) of the lung is a rare and aggressive
tumor similar to small cell lung cancer (SCLC). Thus, it is often treated similarly to SCLC in …

Adjuvant chemotherapy guided by molecular profiling and improved outcomes in early stage, non–small-cell lung cancer

GA Woodard, SX Wang, JR Kratz… - Clinical Lung Cancer, 2018 - Elsevier
Introduction Many early stage non–small-cell lung cancer (NSCLC) patients who are not
considered candidates for adjuvant treatment according to current guidelines do harbor …

A Six‐Gene Signature Predicts Survival of Adenocarcinoma Type of Non‐Small‐Cell Lung Cancer Patients: A Comprehensive Study Based on Integrated Analysis …

H Xie, C Xie - BioMed Research International, 2019 - Wiley Online Library
Background and Goals. To identify a multigene signature model for prognosis of non‐small‐
cell lung cancer (NSCLC) patients, we first found 2146 consensus differentially expressed …

[HTML][HTML] Prognostic markers in lung cancer: is it ready for prime time?

CQ Zhu, MS Tsao - Translational lung cancer research, 2014 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is a heterogeneity disease and to date, specific clinical
factors and tumor stage are established as prognostic markers. Nevertheless, prognosis …

Association between imaging surveillance frequency and outcomes following surgical treatment of early-stage lung cancer

BT Heiden, DB Eaton Jr, SH Chang… - JNCI: Journal of the …, 2023 - academic.oup.com
Background Recent studies have suggested that more frequent postoperative surveillance
imaging via computed tomography following lung cancer resection may not improve …