Hyperbilirubinaemia, presenting as jaundice, is a ubiquitous and frequently benign
condition in newborn babies but is a leading cause of hospitalisation in the first week of life …

Bilirubin, the principal bile pigment, is the end product of heme catabolism. For many years,
bilirubin was thought to have no physiological function other than that of a waste product of …

Heme oxygenase (HO) catalyzes the conversion of heme to carbon monoxide, iron, and
biliverdin, which is immediately reduced to bilirubin (BR). Two HO active isozymes exist …

Peroxynitrite (ONOO−) is known to inactivate important cellular targets and also mediate
oxidative damage in DNA. The present study has demonstrated that phycocyanin, a …

Mildly increased serum bilirubin has recently been suggested as a protective factor, possibly
reducing the risk of coronary artery disease (CAD) by acting as an antioxidant. We tested …

The pathogenesis of atherosclerosis is not fully understood. Oxidized low-density lipoprotein
(LDL) may play an important role in the atherosclerotic process. Epidemiologic studies have …

Translocator proteins (TSPOs) bind steroids and porphyrins, and they are implicated in
many human diseases, for which they serve as biomarkers and therapeutic targets. TSPOs …

High expression of the inducible isoform of heme oxygenase (HO-1) is now well known in
solid tumors in humans and experimental animal models. We reported previously that HO-1 …

Hinds and Stec Bilirubin Signaling 789 protein, which results in enhanced phosphorylation,
transactivation, and DNA binding to PPAR response elements in promoters or enhancers of …

Given the high morbidity and mortality rates associated with pulmonary inflammation in
sepsis, there is a pressing need for new therapeutic modalities to prevent acute respiratory …