Recent technical advances have dramatically increased the power and scope of structural
biology. New developments in high-resolution cryo-electron microscopy, serial X-ray …

Cyclic nucleotide–gated (CNG) channels are key to the signal transduction machinery of
certain sensory modalities both in vertebrate and invertebrate organisms. They translate a …

We present CryoGAN, a new paradigm for single-particle cryo-electron microscopy (cryo-
EM) reconstruction based on unsupervised deep adversarial learning. In single-particle cryo …

To protect themselves from host attack, numerous jumbo bacteriophages establish a phage
nucleus—a micron-scale, proteinaceous structure encompassing the replicating phage …

Focal adhesion kinase (FAK) is a key component of the membrane proximal signaling layer
in focal adhesion complexes, regulating important cellular processes, including cell …

Over the past decade, the structural biology of membrane proteins (MPs) has taken a new
turn thanks to epoch-making technical progress in single-particle electron cryo-microscopy …

This article documents a keynote seminar presented at the IUCr Congress in Prague, 2021.
The cryo-EM method microcrystal electron diffraction is described and put in the context of …

Here, we demonstrate atomic-resolution scanning transmission electron microscopy (STEM)
imaging of light elements in small organic molecules on graphene. We use low-dose, room …

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions within proteins
(IDRs) serve an increasingly expansive list of biological functions, including regulation of …

Amphiphilic molecules that can crystallize often form molecularly thin nanosheets in
aqueous solutions. The possibility of atomic-scale corrugations in these structures has not …