Since the mid-1990s, dendritic cells have been used in clinical trials as cellular mediators for
therapeutic vaccination of patients with cancer. Dendritic cell-based immunotherapy is safe …

Cancer immunotherapy attempts to harness the power and specificity of the immune system
to treat tumours. The molecular identification of human cancer-specific antigens has allowed …

Vaccines represent one of the greatest triumphs of modern medicine. Despite the common
origins of vaccinology and immunology more than 200 years ago, the two disciplines have …

Arginine metabolism has been a key catabolic and anabolic process throughout the
evolution of the immune response. Accruing evidence indicates that arginine-catabolizing …

Macrophage and dendritic cell (DC) are hematopoietic cells found in all tissues in the steady
state that share the ability to sample the environment but have distinct function in tissue …

Dendritic cells (DC) are sentinels of immunity, essential for homeostasis of T cell-dependent
immune responses. Both functions of DC, initiation of antigen-specific T cell immunity and …

Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic
system, specialized in antigen capture, processing, and presentation. The different DC …

CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though
several studies have analyzed Treg frequency in the peripheral blood mononuclear cells …

The effective vaccines developed against a variety of infectious agents, including polio,
measles, and hepatitis B, represent major achievements in medicine. These vaccines …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with
limited therapeutic options. HCC‐induced immunosuppression often leads to ineffectiveness …