Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human
infection and disease on a global scale. These viruses are classified as either arthritogenic …

Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …

The olfactory mucosa is a component of the nasal airway that mediates the sense of smell.
Recent studies point to an important role for the olfactory mucosa as a barrier to both …

Alphaviruses cause severe arthritogenic or encephalitic disease. The E1 structural
glycoprotein is highly conserved in these viruses and mediates viral fusion with host cells …

Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging
from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic …

Eastern equine encephalitis virus (EEEV) is the most virulent alphavirus that infects humans,
and many survivors develop neurological sequelae, including paralysis and intellectual …

Abstract The Togaviridae family, genus, Alphavirus, includes several mosquito-borne human
pathogens with the potential to spread to near pandemic proportions. Most of these are …

Identification of therapeutics against emerging and re-emerging viruses remains a continued
priority that is only reinforced by the recent SARS-CoV-2 pandemic. Advances in …

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of
acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response …

Antibodies are frontline defenders against influenza virus infection, providing protection
through multiple complementary mechanisms. Although a subset of monoclonal antibodies …