Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …

Neuroblastoma is a childhood cancer that resembles developmental stages of the neural
crest. It is not established what developmental processes neuroblastoma cancer cells …

Since the original descriptions of gain-of function mutations in anaplastic lymphoma kinase
(ALK), interest in the role of this receptor tyrosine kinase in neuroblastoma development and …

Simple Summary Neuroblastoma is a tumor of the sympathetic nervous system that
substantially contributes to childhood cancer mortality. Neuroblastoma originates from the …

Abstract Paired Like homeobox 2B (PHOX2B) is a gene crucial for the differentiation of the
neural lineages of the autonomic nervous system (ANS), whose coding mutations cause …

The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the
pathogenesis of different types of human cancers, including neuroblastoma (NB). In NB, ALK …

Peripheral neuroblastic tumors are the most commonly occurring extracranial tumors in
children. Although a reliable diagnosis is achievable in the majority of cases, diagnosis of a …

Background Neuroblastoma (NB) is a severe pediatric tumor originating from neural crest
derivatives and accounting for 15% of childhood cancer mortality. The heterogeneous and …

Genetically engineered mouse models (GEMM) have made major contributions to a
molecular understanding of several adult cancers and these results are increasingly being …