Introduction: Chemokine receptors are important therapeutic targets for the treatment of
many human diseases. This study will provide an overview of approved chemokine receptor …

SUMMARY HIV-1 DNA exists in nonintegrated linear and circular episomal forms and as
integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear …

Combination therapy with three antiretroviral agents has been integral to successful HIV-1
treatment since 1996. Although the efficacy, adverse effects, and toxicities of contemporary …

Introduction: For two decades, triple combinations of antiretrovirals have been the standard
treatment for HIV infection. The challenges of such lifelong therapy include long-term side …

Antiretroviral (ARV) therapy, comprising a backbone of two nucleos (t) ide reverse
transcriptase inhibitors (NRTI s) plus another ARV, is the recognized standard of care (SOC) …

Introduction: Despite the efficacy and safety of antiretroviral therapy, new treatment options
are needed to address the concerns of patients and physicians regarding long-term …

Introduction: Current guidelines recommend a 2-drug antiretroviral regimen as an alternative
to triple antiretroviral therapy (ART) in selected patients to reduce long-term toxicity and …

Background Dual therapy (DT) with a ritonavir-boosted PI (PI/r) plus lamivudine has proven
non-inferior (12% margin) to triple therapy (TT) with PI/r plus two nucleos (t) ide reverse …

As people live longer with HIV infection, there has been a resurgence of interest in
challenging the use of three-drug therapy, including two nucleoside reverse transcriptase …

Introduction As HIV has become a manageable chronic condition, a renewed and increased
interest in challenging traditional three-drug HIV therapies and moving toward two-drug …