The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …

Besides BRCA1 and BRCA2, several other inheritable mutations have been identified that
increase ovarian cancer risk. Surgical excision of the fallopian tubes and ovaries reduces …

Without preventive interventions, women with germline pathogenic variants in BRCA1 or
BRCA2 have high lifetime risks for breast cancer and tubo-ovarian cancer. The increased …

Importance Women with pathogenic variants inBRCA1andBRCA2are at high risk of
developing breast and ovarian cancers. They usually undergo intensive cancer surveillance …

Background Women testing positive for BRCA1/2 pathogenic variants have high lifetime
risks of breast cancer (BC) and ovarian cancer. The effectiveness of risk reducing surgery …

Simple Summary Women with a BRCA1/2 germline pathogenic variant (GPV) are advised to
undergo surgery to remove their ovaries and fallopian tubes at a young age to prevent …

Aim BRCA mutation carriers have a high lifetime risk of developing breast cancer (BC) and
ovarian cancer (OC). Risk-reducing salpingo-oophorectomy (RRSO) has been shown to …

Personalized management of patients at risk ideally should involve a multidisciplinary team
of not only genetic counselors and surgeons, but also women's health or menopause …

Background: The lack of consensus on whether bilateral oophorectomy impacts risk of
developing breast cancer among BRCA1 mutation carriers might be attributed to various …

Purpose It is not known whether the risk of breast cancer among BRCA1 and BRCA2
mutation carriers after age 60 is high enough to justify intensive screening or prophylactic …