Advancing models of neural development with biomaterials

JG Roth, MS Huang, TL Li, VR Feig, Y Jiang… - Nature Reviews …, 2021 - nature.com
Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

[HTML][HTML] Collagen for neural tissue engineering: Materials, strategies, and challenges

WH Huang, SL Ding, XY Zhao, K Li, HT Guo… - Materials Today Bio, 2023 - Elsevier
Neural tissue engineering (NTE) has made remarkable strides in recent years and holds
great promise for treating several devastating neurological disorders. Selecting optimal …

[HTML][HTML] 3D bioprinting pluripotent stem cell derived neural tissues using a novel fibrin bioink containing drug releasing microspheres

R Sharma, IPM Smits, L De La Vega, C Lee… - … in bioengineering and …, 2020 - frontiersin.org
3D bioprinting combines cells with a supportive bioink to fabricate multiscale, multi-cellular
structures that imitate native tissues. Here, we demonstrate how our novel fibrin-based …

[HTML][HTML] Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery

SM Willerth, SE Sakiyama-Elbert - StemJournal, 2019 - content.iospress.com
Combining stem cells with biomaterial scaffolds serves as a promising strategy for
engineering tissues for both in vitro and in vivo applications. This updated review details …

Bioprinting a novel glioblastoma tumor model using a fibrin-based bioink for drug screening

C Lee, E Abelseth, L De La Vega, SM Willerth - Materials Today Chemistry, 2019 - Elsevier
Glioblastoma multiforme (GBM), a deadly primary brain cancer, exhibits invasive
proliferation into healthy brain tissue. Currently, novel treatment methods are being …

[HTML][HTML] 3D bioprinting human induced pluripotent stem cell-derived neural tissues using a novel lab-on-a-printer technology

L De la Vega, D A. Rosas Gómez, E Abelseth… - Applied Sciences, 2018 - mdpi.com
Featured Application Here, we detail a novel high-throughput method for printing neural
tissues derived from human induced pluripotent stem cells (hiPSCs), which can potentially …

[HTML][HTML] Physical and mechanical characterization of fibrin-based bioprinted constructs containing drug-releasing microspheres for neural tissue engineering …

R Sharma, R Kirsch, KP Valente, MR Perez… - Processes, 2021 - mdpi.com
Three-dimensional bioprinting can fabricate precisely controlled 3D tissue constructs. This
process uses bioinks—specially tailored materials that support the survival of incorporated …

Direct reprogramming of glioblastoma cells into neurons using small molecules

C Lee, M Robinson, SM Willerth - ACS chemical neuroscience, 2018 - ACS Publications
Glioblastoma multiforme, a type of deadly brain cancer, originates most commonly from
astrocytes found in the brain. Current multimodal treatments for glioblastoma minimally …

3D bioprinting human‐induced pluripotent stem cells and drug‐releasing microspheres to produce responsive neural tissues

L De la Vega, L Abelseth, R Sharma… - Advanced …, 2021 - Wiley Online Library
3D bioprinting can produce complex human tissue mimics using stem cells (SCs). Herein,
cylindrical constructs containing human‐induced pluripotent stem cell (hiPSC)‐derived …

Microfluidic generation of therapeutically relevant polycaprolactone (PCL) microparticles: computational and experimental approaches

A Forigua, A Dalili, R Kirsch, SM Willerth… - ACS Applied Polymer …, 2022 - ACS Publications
Drug releasing microparticles play an important role in drug delivery as they can be used for
site specific delivery as well as control over the release time of therapeutics. The use of …