Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

Transforming growth factor-β (TGF-β) proteins regulate cell function, and have key roles in
development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad …

TGF-β signaling controls a plethora of cellular responses and figures prominently in animal
development. Recent cellular, biochemical, and structural studies have revealed significant …

Smad transcription factors lie at the core of one of the most versatile cytokine signaling
pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent …

SCF complexes are the largest family of E3 ubiquitin–protein ligases and mediate the
ubiquitination of diverse regulatory and signalling proteins. Here we present the crystal …

Transforming growth factor–β (TGF-β) superfamily members regulate a plethora of
developmental processes, and disruption of their activity has been implicated in a variety of …

Smad proteins transduce signals from transforming growth factor-β (TGF-β) superfamily
ligands that regulate cell proliferation, differentiation and death through activation of receptor …

Members of the TGF-β superfamily, which includes TGF-βs, growth differentiation factors,
bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic …

Members of the transforming growth factor‐β (TGF‐β) superfamily bind to two different
serine/threonine kinase receptors, ie type I and type II receptors. Upon ligand binding, type I …

Transforming growth factor-β (TGF-β) is a secreted polypeptide that signals via receptor
serine/threonine kinases and intracellular Smad effectors. TGF-β inhibits proliferation and …