CAR T‐cell therapy in hematologic malignancies: a voyage in progress

SA Holstein, MA Lunning - Clinical Pharmacology & …, 2020 - Wiley Online Library
The development of chimeric antigen receptor (CAR) T‐cell therapy for select hematological
malignancies represents one of the most remarkable therapeutic advances in the past …

Rapidly changing myeloma epidemiology in the general population: Increased incidence, older patients, and longer survival

I Turesson, M Bjorkholm, CH Blimark… - European journal of …, 2018 - Wiley Online Library
The incidence of multiple myeloma is characterized by a steep increase with advancing age.
Dramatic improvements in survival have been reported in clinical trials; however, elderly …

CC-90009: a cereblon E3 ligase modulating drug that promotes selective degradation of GSPT1 for the treatment of acute myeloid leukemia

JD Hansen, M Correa, M Alexander… - Journal of medicinal …, 2021 - ACS Publications
Acute myeloid leukemia (AML) is marked by significant unmet clinical need due to both poor
survival and high relapse rates where long-term disease control for most patients with …

Mortality trends in multiple myeloma after the introduction of novel therapies in the United States

M Binder, B Nandakumar, SV Rajkumar, P Kapoor… - Leukemia, 2022 - nature.com
Advances in the understanding of disease biology, drug development, and supportive care
have led to improved outcomes in multiple myeloma. Given that these improvements have …

Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and …

S Rögnvaldsson, TJ Love, S Thorsteinsdottir… - Blood Cancer …, 2021 - nature.com
Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma
(MM). Population-based screening for MGUS could identify candidates for early treatment in …

Genomic classification and individualized prognosis in multiple myeloma

F Maura, AR Rajanna, B Ziccheddu… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE Outcomes for patients with newly diagnosed multiple myeloma (NDMM) are
heterogenous, with overall survival (OS) ranging from months to over 10 years. METHODS …

Probabilistic machine learning for healthcare

IY Chen, S Joshi, M Ghassemi… - Annual review of …, 2021 - annualreviews.org
Machine learning can be used to make sense of healthcare data. Probabilistic machine
learning models help provide a complete picture of observed data in healthcare. In this …

Novel agents as main drivers for continued improvement in survival in multiple myeloma

B Puertas, V González-Calle, E Sobejano-Fuertes… - Cancers, 2023 - mdpi.com
Simple Summary Survival of patients with multiple myeloma continues to improve over time
in parallel with the development of new treatments. The combination of novel agents in the …

Epidemiology, genetics and treatment of multiple myeloma and precursor diseases

K Hemminki, A Försti, R Houlston… - International journal of …, 2021 - Wiley Online Library
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of
plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 …

Financial toxicity in hematological malignancies: a systematic review

E Ouchveridze, R Banerjee, A Desai, M Aziz… - Blood cancer …, 2022 - nature.com
Hematologic malignancy outcomes have remarkably improved in the past decade with
further advancement expected in future years. However, the detrimental effects of financial …