The greater inflammatory pathway—High clinical potential by innovative predictive, preventive, and personalized medical approach

MG Maturo, M Soligo, G Gibson, L Manni, C Nardini - EPMA Journal, 2020 - Springer
Background and limitations Impaired wound healing (WH) and chronic inflammation are
hallmarks of non-communicable diseases (NCDs). However, despite WH being a …

Determining the balance between drug efficacy and safety by the network and biological system profile of its therapeutic target

XX Li, J Yin, J Tang, Y Li, Q Yang, Z Xiao… - Frontiers in …, 2018 - frontiersin.org
One of the most challenging puzzles in drug discovery is the identification and
characterization of candidate drug of well-balanced profile between efficacy and safety. So …

[PDF][PDF] NetworkToolbox: Methods and Measures for Brain, Cognitive, and Psychometric Network Analysis in R.

AP Christensen - R J., 2018 - files.osf.io
This article introduces the NetworkToolbox package for R. Network analysis offers an
intuitive perspective on complex phenomena via models depicted by nodes (variables) and …

A spatial interaction incorporated betweenness centrality measure

X Wu, W Cao, J Wang, Y Zhang, W Yang, Y Liu - Plos one, 2022 - journals.plos.org
Betweenness centrality (BC) is widely used to identify critical nodes in a network by
exploring the ability of all nodes to act as intermediaries for information exchange. However …

Estimating pedestrian flows on street networks: revisiting the betweenness index

A Sevtsuk - Journal of the American Planning Association, 2021 - Taylor & Francis
Problem, research strategy, and findings City governments and planners alike commonly
seek to increase pedestrian activity on city streets as part of broader sustainability …

Windows scanning multiomics: Integrated metabolomics and proteomics

J Shi, J Zhao, Y Zhang, Y Wang, CP Tan… - Analytical …, 2023 - ACS Publications
Metabolomics and proteomics offer significant advantages in understanding biological
mechanisms at two hierarchical levels. However, conventional single omics analysis faces …

Resilience or robustness: identifying topological vulnerabilities in rail networks

A Pagani, G Mosquera, A Alturki… - Royal Society …, 2019 - royalsocietypublishing.org
Many critical infrastructure systems have network structures and are under stress. Despite
their national importance, the complexity of large-scale transport networks means that we do …

Understanding railway operational accidents using network theory

J Liu, F Schmid, W Zheng, J Zhu - Reliability Engineering & System Safety, 2019 - Elsevier
Learning from past accidents in railway operations is valuable for ensuring the future safety
of railway operations. Railway operational accidents are of different types, such as collisions …

Distinctiveness centrality in social networks

A Fronzetti Colladon, M Naldi - Plos one, 2020 - journals.plos.org
The determination of node centrality is a fundamental topic in social network studies. As an
addition to established metrics, which identify central nodes based on their brokerage …

A centrality model for directed graphs based on the Two-Way-Random Path and associated indices for characterizing the nodes

M Curado, R Rodriguez, F Terroso-Saenz… - Journal of …, 2022 - Elsevier
Centrality metrics are one of the most meaningful features in a large number of real-world
network systems. In that sense, the Betweenness centrality is a widely used measurement …