The ongoing characterization of the genetic and epigenetic alterations in the gliomas has
already improved the classification of these heterogeneous tumors and enabled the …

Primary brain tumors have a significant infiltrative capacity as their reappearance after
resection usually occurs within 2cm of the tumor margin. Local delivery method such as …

Purpose: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer with a
median survival of only 12 to 15 months. Current standard treatment consists of surgery …

Transforming growth factor (TGF)-β is known to promote tumor invasion and metastasis.
Although bone morphogenetic proteins (BMPs), members of the TGF-β family, are …

Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial,
prognostic marker of human glioblastoma multiforme (GBM). However, its functional role and …

One of the most promising new chemotherapeutic strategies is the RNA interference (RNAi)-
based approach, wherein small double-stranded RNA molecules can sequencespecifically …

Tumor receptors play an important role in carcinogenesis and tumor growth and have been
some of the earliest targets for tumor-specific therapy, for example, the estrogen receptor in …

Nerve growth factor receptor (NGFR), a member of kinase protein, is emerging as an
important target for Glioblastoma (GBM) treatment. Overexpression of NGFR is observed in …

The resistance of glioma cells to a number of antitumor agents and the highly invasive
nature of glioma cells that escape the primary tumor mass are key impediments to the …

Brain tumor is one of the most challenging diseases to treat. The major obstacle in the
specific drug delivery to brain is blood–brain barrier (BBB). Mostly available anti-cancer …