The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The
NAD+-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms …

Vascular calcification (VC) is regarded as an important pathological change lacking effective
treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern,
and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is …

Abstract Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide
(NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them …

The significant increase in human lifespan during the past century confronts us with great
medical challenges. To meet these challenges, the mechanisms that determine healthy …

Mammalian sirtuins (SIRT1 through SIRT7) are members of a highly conserved family of
NAD+-dependent protein deacetylases that function in metabolism, genome maintenance …

L1 retrotransposons are an abundant class of transposable elements that pose a threat to
genome stability and may have a role in age-related pathologies such as cancer. Recent …