The unusual acidic pH of the abscess milieu is an adverse factor that decreases the
therapeutic efficacy of traditional antibiotics. Moreover, avoiding both the undesired killing of …

With the recent increase in computing power, the molecular modeling community is now
more focused on improving the accuracy and overall quality of biomolecular simulations. For …

Peptide dendrimers are good candidates for diverse biomedical applications due to their
biocompatibility and low toxicity. The local orientational mobility of groups with different …

In this paper, we perform computer simulation of two lysine-based dendrimers with Lys-2Lys
and Lys-2Gly repeating units. These dendrimers were recently studied experimentally by …

Dendrimers have attracted growing attention in the field of drug delivery as smart
nanoengineered polymers. They are defined as novel three-dimensional polymers with …

Electrostatic interactions play a pivotal role in the structure and mechanism of action of most
biomolecules. There are several conceptually different methods to deal with electrostatics in …

Peptide dendrimers are a type of branched, symmetric, and topologically well-defined
molecule that have already been used as delivery systems for nucleic acid transfection …

To examine the usability of the imine-linked amino acid-based dendrimeric structures in the
smart drug delivery applications, molecular dynamics simulation studies were carried out. 20 …

Background: Dendrimers and hyperbranched polymers are emerging polymer architectures
that attract increasing attention due to their unique topological structure and interesting …

The ability to sense and react to external and internal pH changes is a survival requirement
for any cell. pH homeostasis is tightly regulated, and even minor disruptions can severely …