Cell-based strategies for IVD repair: clinical progress and translational obstacles

ALA Binch, JC Fitzgerald, EA Growney… - Nature Reviews …, 2021 - nature.com
Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …

Characteristics and mechanisms of resorption in lumbar disc herniation

P Yu, F Mao, J Chen, X Ma, Y Dai, G Liu, F Dai… - Arthritis Research & …, 2022 - Springer
Lumbar disc herniation (LDH) can be spontaneously absorbed without surgical treatment.
However, the pathogenesis and physiological indications for predicting protrusion …

Inflammation in intervertebral disc degeneration and regeneration

M Molinos, CR Almeida, J Caldeira… - Journal of the …, 2015 - royalsocietypublishing.org
Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a
problem with a heavy economic burden, which has been increasing in prevalence as …

The molecular basis of intervertebral disc degeneration

CK Kepler, RK Ponnappan, CA Tannoury, MV Risbud… - The Spine Journal, 2013 - Elsevier
BACKGROUND: Intervertebral disc (IVD) degeneration remains a clinically important
condition for which treatment is costly and relatively ineffective. The molecular basis of …

What is intervertebral disc degeneration, and what causes it?

MA Adams, PJ Roughley - Spine, 2006 - journals.lww.com
Study Design. Review and reinterpretation of existing literature. Objective. To suggest how
intervertebral disc degeneration might be distinguished from the physiologic processes of …

[HTML][HTML] The immune privilege of the intervertebral disc: implications for intervertebral disc degeneration treatment

Z Sun, B Liu, ZJ Luo - International journal of medical sciences, 2020 - ncbi.nlm.nih.gov
The intervertebral disc (IVD) is the largest avascular organ of the body. It is composed of
three parts: the nucleus pulposus (NP), the annulus fibrosus (AF) and the cartilaginous …

Advancing the cellular and molecular therapy for intervertebral disc disease

D Sakai, S Grad - Advanced drug delivery reviews, 2015 - Elsevier
The healthy intervertebral disc (IVD) fulfils the essential function of load absorption, while
maintaining multi-axial flexibility of the spine. The interrelated tissues of the IVD, the annulus …

Meniscal fibrocartilage regeneration inspired by meniscal maturational and regenerative process

W Yan, M Maimaitimin, Y Wu, Y Fan, S Ren, F Zhao… - Science …, 2023 - science.org
Meniscus is a complex and crucial fibrocartilaginous tissue within the knee joint. Meniscal
regeneration remains to be a scientific and translational challenge. We clarified that …

[图书][B] The Biomechanics of Back Pain-E-Book

MA Adams, N Bogduk, K Burton, P Dolan - 2012 - books.google.com
Authored by experts of international renown, the new edition of The Biomechanics of Back
Pain forms a bridge between the latest research and the effective clinical management of …

Immuno-modulatory effects of intervertebral disc cells

P Bermudez-Lekerika, KB Crump… - Frontiers in cell and …, 2022 - frontiersin.org
Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …