Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Breast cancer is one of the leading causes of mortality in females. Over the past decades,
intensive efforts have been made to uncover the pathogenesis of breast cancer. Interleukin …

Persistently activated or tyrosine-phosphorylated STAT3 (pSTAT3) is found in 50% of lung
adenocarcinomas. pSTAT3 is found in primary adenocarcinomas and cell lines harboring …

Introduction Signal transducer and activator of transcription 3 (Stat3) is constitutively tyrosine-
phosphorylated in approximately 50% of primary breast carcinomas. A number of different …

Metastatic events to the bone occur frequently in numerous cancer types such as breast,
prostate, lung, and renal carcinomas, melanoma, neuroblastoma, and multiple myeloma …

Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-
associated inflammation contributes to tumor initiation and progression. However, it remains …

The increasing incidence of resistance to chemotherapeutic agents has become a major
issue in the treatment of oral cancer (OC). Epithelial-mesenchymal transition (EMT) has …

Background Many cancers, including breast cancer, have been identified with increased
levels of phosphorylated or the active form of Signal Transducers and Activators of …

One of the major problems related with the curative treatment of cancer patients is resistance
against anticancer drugs. This resistance, which may occur from the beginning or is evident …

Abstract Development of metastasis in peripheral tissues is a major problem in the fight to
cure breast cancer. Although it is becoming evident that chronic inflammation can contribute …